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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779]
LigandBDBM14775
Substrate/CompetitorBDBM10851
Meas. Tech.Phosphodiesterase (PDE) Inhibition Assay
IC50 21000±n/a nM
Citation Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed]  Article
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779]
Name:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779]
Synonyms:PDE10A | PDE10_HUMAN | Phosphodiesterase Type 10 (PDE10A) | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A
Type:Enzyme Catalytic Domain
Mol. Mass.:40036.62
Organism:Homo sapiens (Human)
Description:Recombinant catalytic domain (M432-D779) of human PDE10A.
Residue:348
Sequence:
MEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS
CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACL
CHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ
VLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKL
WPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTL
TQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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BDBM14775
BDBM10851
NameBDBM14775
Synonyms:3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401
TypeSmall organic molecule
Emp. Form.C18H18Cl2N2O3
Mol. Mass.381.253
SMILESCOc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Structure
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