Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
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Ligand | BDBM14784 |
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Substrate/Competitor | BDBM10851 |
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Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 15000±n/a nM |
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Citation | Card, GL; Blasdel, L; England, BP; Zhang, C; Suzuki, Y; Gillette, S; Fong, D; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol23:201-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
Synonyms: | DPDE4 | PDE32 | PDE4B | PDE4B_HUMAN | Phosphodiesterase Type 4 (PDE4B) | cAMP-specific 3,5-cyclic phosphodiesterase 4B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 45579.64 |
Organism: | Homo sapiens (Human) |
Description: | RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B. |
Residue: | 398 |
Sequence: | MGSSHHHHHHSSGLVPRGSHMSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHS
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BDBM14784 |
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BDBM10851 |
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Name | BDBM14784 |
Synonyms: | Pyrazole carboxylic ester 7 | cid_707658 | ethyl 3-amino-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate |
Type | Small organic molecule |
Emp. Form. | C13H15N3O3 |
Mol. Mass. | 261.2765 |
SMILES | CCOC(=O)c1c(N)[nH]nc1-c1ccc(OC)cc1 |
Structure |
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