| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII |
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| Ligand | BDBM14884 |
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| Substrate/Competitor | BDBM13777 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | 160±n/a nM |
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| Citation |  Riggs, JR; Hu, H; Kolesnikov, A; Leahy, EM; Wesson, KE; Shrader, WD; Vijaykumar, D; Wahl, TA; Tong, Z; Sprengeler, PA; Green, MJ; Yu, C; Katz, BA; Sanford, E; Nguyen, M; Cabuslay, R; Young, WB Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett16:3197-200 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Coagulation factor VII |
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| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM14884 |
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| BDBM13777 |
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| Name | BDBM14884 |
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| Synonyms: | 1-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}phenyl)phenyl]methyl}-3-thiophen-2-ylurea | 5-azaindole analog 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20N4O2S |
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| Mol. Mass. | 440.517 |
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| SMILES | Oc1c(cccc1-c1cccc(CNC(=O)Nc2cccs2)c1)-c1cc2cnccc2[nH]1 |
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| Structure | 
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