| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor VII |
|---|
| Ligand | BDBM14927 |
|---|
| Substrate/Competitor | BDBM13777 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | 130±n/a nM |
|---|
| Citation |  Shrader, WD; Kolesnikov, A; Burgess-Henry, J; Rai, R; Hendrix, J; Hu, H; Torkelson, S; Ton, T; Young, WB; Katz, BA; Yu, C; Tang, J; Cabuslay, R; Sanford, E; Janc, JW; Sprengeler, PA Factor VIIa inhibitors: gaining selectivity within the trypsin family. Bioorg Med Chem Lett16:1596-600 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Coagulation factor VII |
|---|
| Name: | Coagulation factor VII |
|---|
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51599.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
|---|
| BDBM14927 |
|---|
| BDBM13777 |
|---|
| Name | BDBM14927 |
|---|
| Synonyms: | 2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(2-methoxyphenyl)phenyl]butanedioic acid | 5-amidino benzimidazole analog 38 | CHEMBL381120 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22N4O6 |
|---|
| Mol. Mass. | 474.4654 |
|---|
| SMILES | COc1ccccc1-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
