| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent molecular chaperone HSP82 |
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| Ligand | BDBM15374 |
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| Substrate/Competitor | BDBM2 |
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| Meas. Tech. | Colorimetric Determination of ATPase Activity |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >200000±n/a nM |
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| Citation |  Wright, L; Barril, X; Dymock, B; Sheridan, L; Surgenor, A; Beswick, M; Drysdale, M; Collier, A; Massey, A; Davies, N; Fink, A; Fromont, C; Aherne, W; Boxall, K; Sharp, S; Workman, P; Hubbard, RE Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. Chem Biol11:775-85 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| ATP-dependent molecular chaperone HSP82 |
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| Name: | ATP-dependent molecular chaperone HSP82 |
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| Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein Hsp90 heat-inducible isoform |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 81369.08 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | Histidine-tagged yeast HSP90 was transformed into E. coli and purified (>90%) by metal affinity, gel filtration, and ion-exchange chromatography. |
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| Residue: | 709 |
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| Sequence: | MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDK
KPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDW
EDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPE
WLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSA
FSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLK
AVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAER
EKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRD
SSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDE
PTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
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| BDBM15374 |
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| BDBM2 |
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| Name | BDBM15374 |
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| Synonyms: | 9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine | 9-butyl-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine | CHEMBL113690 | PU3 | Purine-Based Inhibitor 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N5O3 |
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| Mol. Mass. | 371.4335 |
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| SMILES | CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc2c(N)ncnc12 |
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| Structure | 
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