Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 [17-125] |
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Ligand | BDBM221505 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FRET Assay |
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Temperature | 298.15±n/a K |
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IC50 | 0.7528±n/a nM |
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Comments | assayid=2 extracted |
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Citation | Cammarano, CM; Christopher, MP; Dinsmore, C; Doll, RJ; Fradera Llinas, FX; Li, C; Machacek, M; Martinez, M; Nair, LG; Pan, W; Reutershan, MH; Shizuka, M; Steinhuebel, DP; Sun, B; Thompson, CF; Trotter, BW; Wang, Y; Yang, L; Bogen, SL; Voss, ME; Panda, J; Kurissery, AT 2,6,7,8 substituted purines as HDM2 inhibitors US Patent US9540377 Publication Date 1/10/2017 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 [17-125] |
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Name: | E3 ubiquitin-protein ligase Mdm2 [17-125] |
Synonyms: | Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 12522.24 |
Organism: | Homo sapiens (Human) |
Description: | Residue 17 to 125 |
Residue: | 109 |
Sequence: | SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVY
CSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN
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BDBM221505 |
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n/a |
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Name | BDBM221505 |
Synonyms: | 6-{[(1r)-1- cyclobutylethyl]amino}- 8-{[(1s)-1-(3- fluorophenyl)ethyl] amino}-7-[4- (trifluoromethypbenzyl]- 7h-purine-2- carboxylic acid | US9540377, 9.39 |
Type | Small organic molecule |
Emp. Form. | C28H28F4N6O2 |
Mol. Mass. | 556.5545 |
SMILES | C[C@@H](Nc1nc(nc2nc(N[C@@H](C)c3cccc(F)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1 |r| |
Structure |
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