Ki Summary

Reaction Details

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Target

Aldo-keto reductase family 1 member B1

Ligand

BDBM16456

Substrate/Competitor

BDBM16443

Meas. Tech.

In Vitro Aldose Reductase Inhibition Assay

7±n/a

Temperature

297.15±n/a K

IC50

150±n/a nM

Citation

Mylari, BL; Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; O'Gorman, MT; Linhares, MC; Martin, WH; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one. J Med Chem46:2283-6 (2003) [PubMed] Article

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Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

Aldo-keto reductase family 1 member B1

Name:

Aldo-keto reductase family 1 member B1

Synonyms:

Type:

Protein

Mol. Mass.:

35855.50

Organism:

Homo sapiens (Human)

Description:

P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0

Residue:

316

Sequence:

MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

BDBM16456

BDBM16443

Name

BDBM16456

Synonyms:

6-(1-benzofuran-2-sulfonyl)-2,3-dihydropyridazin-3-one | CHEMBL241777 | Heterocyclic Sulfonylpyridazinone, 19h | benzofuran, 22

Type

Small organic molecule

Emp. Form.

C12H8N2O4S

Mol. Mass.

276.268

SMILES

O=c1ccc(n[nH]1)S(=O)(=O)c1cc2ccccc2o1

Structure