Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1 [866-1154]

Ligand

BDBM127767

Substrate/Competitor

n/a

Meas. Tech.

Jak1 Inhibition Assay

IC50

546±n/a nM

Citation

Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US9796724 Publication Date 10/24/2017

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1 [866-1154]

Name:

Tyrosine-protein kinase JAK1 [866-1154]

Synonyms:

Type:

Protein

Mol. Mass.:

33185.74

Organism:

Homo sapiens (Human)

Description:

P23458[866-1154]

Residue:

289

Sequence:

DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK

BDBM127767

n/a

Name

BDBM127767

Synonyms:

US10251889, Example 140 | US10758542, Example 140 | US8791123, 140 | US9782415, Example 140 | US9796724, Example 140

Type

Small organic molecule

Emp. Form.

C23H27FN6O3

Mol. Mass.

454.4973

SMILES

COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1 |r,wD:9.9,27.29,(-7.78,2.63,;-6.29,2.23,;-5.21,3.32,;-5.6,4.81,;-4.51,5.9,;-3.03,5.5,;-1.94,6.59,;-2.63,4.01,;-3.72,2.92,;-3.32,1.43,;-4.22,.19,;-3.32,-1.06,;-1.85,-.58,;-1.85,.96,;-.52,1.73,;-.52,3.27,;.81,4.04,;2.15,3.27,;3.61,3.74,;4.52,2.5,;3.61,1.25,;4.01,-.24,;2.92,-1.33,;5.5,-.64,;5.9,-2.12,;7.38,-2.52,;7.78,-4.01,;6.69,-5.1,;7.09,-6.59,;5.21,-4.7,;4.81,-3.21,;2.15,1.73,;.81,.96,)|

Structure