Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM17054 |
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Substrate/Competitor | Synthetic Chk1 Peptide Substrate |
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Meas. Tech. | Chk1 Enzymatic Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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Ki | 5.6±2.0 nM |
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Comments | The apparent Km for ATP in the Chk1 assay was about 120 uM. |
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Citation | Zhao, B; Bower, MJ; McDevitt, PJ; Zhao, H; Davis, ST; Johanson, KO; Green, SM; Concha, NO; Zhou, BB Structural basis for Chk1 inhibition by UCN-01. J Biol Chem277:46609-15 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM17054 |
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Synthetic Chk1 Peptide Substrate |
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Name: | Synthetic Chk1 Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2323.67 |
Organism: | n/a |
Description: | A synthetic peptide with a sequence flanking Ser-216 of human Cdc25C. |
Residue: | 20 |
Sequence: | |