Reaction Details |
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Target | Lysosomal acid glucosylceramidase |
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Ligand | BDBM18353 |
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Substrate/Competitor | BDBM18352 |
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Meas. Tech. | In Vitro Enzyme Inhibition |
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pH | 5.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 150000±n/a nM |
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Citation | Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. Bioorg Med Chem14:7736-44 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Lysosomal acid glucosylceramidase |
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Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM18353 |
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BDBM18352 |
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Name | BDBM18353 |
Synonyms: | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol | CHEMBL75971 | N-Methyl-DNJ | US9181184, 2 |
Type | natural product |
Emp. Form. | C7H15NO4 |
Mol. Mass. | 177.1983 |
SMILES | CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
Structure |
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