Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM19277 |
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Substrate/Competitor | BDBM19254 |
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Meas. Tech. | IMPDH2 Enzyme Inhibition and Human T-Lymphoblast (CEM) Proliferation Inhibition Assays |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 11±5.9 nM |
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EC50 | 830±690 nM |
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Citation | Watterson, SH; Chen, P; Zhao, Y; Gu, HH; Dhar, TG; Xiao, Z; Ballentine, SK; Shen, Z; Fleener, CA; Rouleau, KA; Obermeier, M; Yang, Z; McIntyre, KW; Shuster, DJ; Witmer, M; Dambach, D; Chao, S; Mathur, A; Chen, BC; Barrish, JC; Robl, JA; Townsend, R; Iwanowicz, EJ Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J Med Chem50:3730-42 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM19277 |
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BDBM19254 |
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Name | BDBM19277 |
Synonyms: | 2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydroacridine-3-carboxamide | Acridone-Based Inhibitor, 4a |
Type | Small organic molecule |
Emp. Form. | C23H19FN2O2 |
Mol. Mass. | 374.4076 |
SMILES | CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccccc1 |
Structure |
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