Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGrowth hormone secretagogue receptor type 1
LigandBDBM19360
Substrate/Competitor125I-His9-ghrelin
Meas. Tech.Receptor Binding Studies and GHS-R Ca2+ Flux Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 1670±n/a nM
EC50>10000±n/a nM
Citation Xin, Z; Serby, MD; Zhao, H; Kosogof, C; Szczepankiewicz, BG; Liu, M; Liu, B; Hutchins, CW; Sarris, KA; Hoff, ED; Falls, HD; Lin, CW; Ogiela, CA; Collins, CA; Brune, ME; Bush, EN; Droz, BA; Fey, TA; Knourek-Segel, VE; Shapiro, R; Jacobson, PB; Beno, DW; Turner, TM; Sham, HL; Liu, G Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. J Med Chem49:4459-69 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19360
125I-His9-ghrelin
Name:125I-His9-ghrelin
Synonyms:radiolabeled peptide ligand
Type:Peptide
Mol. Mass.:9033.11
Organism:n/a
Description:n/a
Residue:82
Sequence:
GLYSERSERCTANYLPHELESERPRGLHISGLNARGVALGLNGLNARGLYSGLSERLYSL
YSPRPRALALYSLEGLNPRARG