| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM19352 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | DHFR Assay |
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| pH | 7.3±n/a |
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| Temperature | 310.15±n/a K |
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| Comments | 78% inhibition @ 1 uM |
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| Citation |  Xin, Z; Serby, MD; Zhao, H; Kosogof, C; Szczepankiewicz, BG; Liu, M; Liu, B; Hutchins, CW; Sarris, KA; Hoff, ED; Falls, HD; Lin, CW; Ogiela, CA; Collins, CA; Brune, ME; Bush, EN; Droz, BA; Fey, TA; Knourek-Segel, VE; Shapiro, R; Jacobson, PB; Beno, DW; Turner, TM; Sham, HL; Liu, G Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. J Med Chem49:4459-69 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM19352 |
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| BDBM18044 |
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| Name | BDBM19352 |
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| Synonyms: | 2,4-diaminopyrimidine-based antagonist, 7 | 6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-1,3-benzodiazol-5-yl}pyrimidine-2,4-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6O2S |
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| Mol. Mass. | 422.503 |
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| SMILES | CCc1nc(N)nc(N)c1-c1ccc2n(Cc3ccc(cc3)S(C)(=O)=O)cnc2c1 |
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| Structure | 
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