Reaction Details | |||
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Report a problem with these data | |||
Target | Apelin receptor | ||
Ligand | BDBM269583 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | [35S]GTPγS Binding | ||
EC50 | 2.00±n/a nM | ||
Citation | Chen, N; Chen, X; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X; Yang, K; Debenedetto, MV; Hedley, SJ Intermediates for preparing triazole agonists of the APJ receptor US Patent US9845310 Publication Date 12/19/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
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BDBM269583 | |||
n/a | |||
Name | BDBM269583 | ||
Synonyms: | (1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-(1-methylethoxy)-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide | US10058550, Example 97.0 | US10221162, Example 97.0 | US9845310, Example 97.0 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H33N7O6S | ||
Mol. Mass. | 583.659 | ||
SMILES | COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-10.64,-1.82,;-9.16,-2.22,;-8.07,-1.13,;-8.47,.36,;-7.38,1.45,;-5.89,1.05,;-5.49,-.44,;-6.58,-1.53,;-4,-.84,;-3.53,-2.3,;-1.99,-2.3,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;6.49,-2.38,;5.16,-4.69,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-6.76,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,)| | ||
Structure |