Reaction Details | |||
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Report a problem with these data | |||
Target | Apelin receptor | ||
Ligand | BDBM363199 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | [35S]GTPγS Binding | ||
EC50 | 9.50±n/a nM | ||
Citation | Chen, N; Chen, X; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X; Yang, K; Debenedetto, MV; Hedley, SJ Intermediates for preparing triazole agonists of the APJ receptor US Patent US9845310 Publication Date 12/19/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
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BDBM363199 | |||
n/a | |||
Name | BDBM363199 | ||
Synonyms: | (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-1-(5-methoxypyrazin-2-yl)propane-2-sulfonamide | US9845310, Example 309.0 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27N7O6S | ||
Mol. Mass. | 541.579 | ||
SMILES | COc1cnc(cn1)[C@@H](O)[C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC |r,wU:10.11,8.9,(-1.48,3.63,;-2.57,4.71,;-4.06,4.32,;-4.46,2.83,;-5.95,2.43,;-7.03,3.52,;-6.64,5.01,;-5.15,5.4,;-8.52,3.12,;-8.92,1.63,;-9.61,4.21,;-9.21,5.7,;-11.1,3.81,;-11.87,2.48,;-10.33,2.48,;-12.19,4.9,;-13.68,4.5,;-14.15,3.04,;-15.69,3.04,;-16.17,4.5,;-17.71,4.5,;-18.48,3.17,;-20.02,3.17,;-20.79,4.5,;-20.02,5.83,;-20.79,7.17,;-18.48,5.83,;-14.92,5.41,;-14.92,6.95,;-16.25,7.72,;-17.59,6.95,;-18.92,7.72,;-16.25,9.26,;-14.92,10.03,;-13.59,9.26,;-13.59,7.72,;-12.25,6.95,;-10.92,7.72,)| | ||
Structure |