Reaction Details | |||
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Report a problem with these data | |||
Target | Apelin receptor | ||
Ligand | BDBM269814 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | [35S]GTPγS Binding | ||
EC50 | 4.00±n/a nM | ||
Citation | Chen, N; Chen, X; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X; Yang, K; Debenedetto, MV; Hedley, SJ Intermediates for preparing triazole agonists of the APJ receptor US Patent US9845310 Publication Date 12/19/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
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BDBM269814 | |||
n/a | |||
Name | BDBM269814 | ||
Synonyms: | (2R)N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-2-hydroxy-2-(3-methyl-5-isoxazolyl)ethanesulfonamide or (2S)N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-2-hydroxy-2-(3-methyl-5-isoxazolyl)ethanesulfonamide | US10058550, Example 337.0 | US10058550, Example 338.0 | US10221162, Example 338.0 | US9845310, Example 338.0 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H24N6O7S | ||
Mol. Mass. | 516.527 | ||
SMILES | COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cc(C)no2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-7.29,-14.62,;-7.69,-13.13,;-6.6,-12.04,;-7,-10.55,;-5.91,-9.46,;-4.42,-9.86,;-4.02,-11.35,;-5.11,-12.44,;-2.69,-12.12,;-2.21,-13.58,;-.67,-13.58,;-.2,-12.12,;1.14,-11.35,;2.47,-12.12,;1.38,-13.21,;3.56,-13.21,;3.56,-11.03,;5.05,-11.43,;5.44,-12.92,;6.13,-10.34,;6.13,-8.8,;7.6,-8.32,;8.37,-6.99,;8.5,-9.57,;7.6,-10.81,;-1.44,-11.21,;-1.44,-9.31,;-2.78,-8.54,;-4.11,-9.31,;-5.45,-8.54,;-2.78,-7,;-1.44,-6.23,;-.11,-7,;-.11,-8.54,;1.22,-9.31,;2.56,-8.54,)| | ||
Structure |