Reaction Details |
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Target | Sphingosine 1-phosphate receptor 5 |
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Ligand | BDBM22225 |
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Substrate/Competitor | BDBM10852 |
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Meas. Tech. | Ligand-Induced Uptake of [35S]-GTP-gamma-S |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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EC50 | 3.9±n/a nM |
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Citation | Yan, L; Huo, P; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Mandala, SM SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties. Bioorg Med Chem Lett17:828-31 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sphingosine 1-phosphate receptor 5 |
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Name: | Sphingosine 1-phosphate receptor 5 |
Synonyms: | EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41796.42 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 398 |
Sequence: | MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
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BDBM22225 |
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BDBM10852 |
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Name | BDBM22225 |
Synonyms: | 3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)butanoic acid | 3-arylpropionic acid derivative, 7b |
Type | Small organic molecule |
Emp. Form. | C23H23F3N2O4 |
Mol. Mass. | 448.4349 |
SMILES | CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(cc1C)C(C)CC(O)=O |
Structure |
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