| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Ligand | BDBM22264 |
|---|
| Substrate/Competitor | BDBM22231 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 11±n/a nM |
|---|
| Citation |  Weinstein, DS; Liu, W; Ngu, K; Langevine, C; Combs, DW; Zhuang, S; Chen, C; Madsen, CS; Harper, TW; Robl, JA Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg Med Chem Lett17:5115-20 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Synonyms: | 15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 75309.71 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | 15-LO enzyme was purified from phenylhydrazine treated rabbits. |
|---|
| Residue: | 663 |
|---|
| Sequence: | MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
|
|
|
|---|
| BDBM22264 |
|---|
| BDBM22231 |
|---|
| Name | BDBM22264 |
|---|
| Synonyms: | 2,4,5-tri-substituted imidazole, 21l | {[(3R)-1-(3,4-dichlorophenyl)pyrrolidin-3-yl](methyl)sulfamoyl}({2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazol-4-yl]ethyl})amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29Cl2N5O3S2 |
|---|
| Mol. Mass. | 606.587 |
|---|
| SMILES | [H][C@]1(CCN(C1)c1ccc(Cl)c(Cl)c1)N(C)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
