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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM127662 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Jak2 Inhibition Assay | ||
| IC50 | 1.20±n/a nM | ||
| Citation |  Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US10251889 Publication Date 4/9/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM127662 | |||
| n/a | |||
| Name | BDBM127662 | ||
| Synonyms: | US10251889, Example 35 | US10758542, Example 35 | US8791123, 35 | US9782415, Example 35 | US9796724, Example 35 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26FN5O2 | ||
| Mol. Mass. | 423.4832 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| | ||
| Structure | 
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