| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Ligand | BDBM375225 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | IDH1-R132H and IDH1-R132C Enzymatic Assay |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors US Patent US10253015 Publication Date 4/9/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46607.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75874[R132C] |
|---|
| Residue: | 414 |
|---|
| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
|---|
| BDBM375225 |
|---|
| n/a |
|---|
| Name | BDBM375225 |
|---|
| Synonyms: | 6-[({6-chloro-7-[2-(4- | US10253015, Compound I-85 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27ClN6O4S |
|---|
| Mol. Mass. | 531.027 |
|---|
| SMILES | Cc1nc(NCc2cc3cc(Cl)c(OCCN4CCN(CC4)S(C)(=O)=O)cc3[nH]c2=O)ccc1C#N |
|---|
| Structure | 
|
|---|
Search and Browse
