Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
B2 bradykinin receptor (RAT) | BDBM50370083 (CHEMBL1907651) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranes | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319772 ((2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-trimethyl-6...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319776 ((2,2'-dimethylbiphenyl-4-yl)((1S,5R)-1,3,3-trimeth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319799 ((4-(1H-indol-3-yl)-3-methoxyphenyl)((1S,5R)-1,3,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19423 (HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of MIT and Harvard Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw... | Bioorg Med Chem 24: 4008-4015 (2016) Article DOI: 10.1016/j.bmc.2016.06.040 BindingDB Entry DOI: 10.7270/Q23B6220 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442142 (CHEMBL2441275) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50012990 (6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranes | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50012990 (6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Agonist activity was tested in vitro against Dopamine receptor from rat brain membranes with [3H]ADT-6,7-dihydroxy-2-aminotetralin] | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50007423 ((R)6-Allyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qui...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranes | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442141 (CHEMBL2441276) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442143 (CHEMBL2441274) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50370077 (CHEMBL1907652) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranes | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319774 ((3-chloro-2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442145 (CHEMBL2441271) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM85095 (CAS_151171 | CONIVAPTAN | NSC_151171 | YM087) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V2 receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319788 (CHEMBL1084325 | N-(2'-methoxy-4'-((1S,5R)-1,3,3-tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442146 (CHEMBL2441270) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50012991 (6-Cyclopropylmethyl-5,6,6a,7-tetrahydro-4H-dibenzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranes | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM85095 (CAS_151171 | CONIVAPTAN | NSC_151171 | YM087) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50113263 ((S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobe...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranes | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50409120 (CHEMBL2112044 | CHEMBL2112937) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranes | J Med Chem 43: 769-71 (2000) BindingDB Entry DOI: 10.7270/Q2XD10W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM50442149 (CHEMBL2441267) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319780 ((2-chloro-5-methoxy-2'-methylbiphenyl-4-yl)((1S,5R...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50113263 ((S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobe...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranes | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319782 ((2-methoxy-2',6'-dimethylbiphenyl-4-yl)((1S,5R)-1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50409120 (CHEMBL2112044 | CHEMBL2112937) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranes | J Med Chem 43: 769-71 (2000) BindingDB Entry DOI: 10.7270/Q2XD10W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442139 (CHEMBL2441273) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319806 ((3-methoxy-4-(quinolin-8-yl)phenyl)((1S,5R)-1,3,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319797 ((4-(benzo[b]thiophen-3-yl)-3-methoxyphenyl)((1S,5R...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (Homo sapiens (Human)) | BDBM50409527 (CHEMBL2112283) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cells | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319792 ((2-methoxy-4'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50012994 (6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranes | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442147 (CHEMBL2441269) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319787 (2'-methoxy-N-methyl-4'-((1S,5R)-1,3,3-trimethyl-6-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.03 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319803 ((4-(2-chloro-1,2-pyridin-3-yl)-3-methoxyphenyl)((1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50023737 (6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Binding affinity against dopamine agonist sites from rat brain corpus striatal preparations using [3H]ADTN | J Med Chem 31: 1392-6 (1988) BindingDB Entry DOI: 10.7270/Q2WW7GP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50041628 ((2S,3S,5R)-8-(3-Fluoro-propyl)-3-(4-iodo-phenyl)-8...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals International Curated by ChEMBL | Assay Description Binding affinity for dopamine transporters in rat brain tissue. | J Med Chem 37: 1558-61 (1994) BindingDB Entry DOI: 10.7270/Q2P55P4H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50041625 ((2S,5R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals International Curated by ChEMBL | Assay Description Binding affinity for dopamine transporters in rat brain tissue. | J Med Chem 37: 1558-61 (1994) BindingDB Entry DOI: 10.7270/Q2P55P4H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (Homo sapiens (Human)) | BDBM50409529 (CHEMBL2112221) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cells | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50012994 (6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Agonist activity was tested in vitro against Dopamine receptor from rat brain membranes with [3H]ADT-6,7-dihydroxy-2-aminotetralin] | J Med Chem 33: 39-44 (1990) BindingDB Entry DOI: 10.7270/Q2183732 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM19423 (HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of MIT and Harvard Curated by ChEMBL | Assay Description Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled... | Bioorg Med Chem 24: 4008-4015 (2016) Article DOI: 10.1016/j.bmc.2016.06.040 BindingDB Entry DOI: 10.7270/Q23B6220 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442140 (CHEMBL2441277) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (RAT) | BDBM50085685 (4-benzhydrylamino(thioxo)methylhydrazine-3-nitrobe...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranes | J Med Chem 43: 769-71 (2000) BindingDB Entry DOI: 10.7270/Q2XD10W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM50442149 (CHEMBL2441267) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins | ACS Med Chem Lett 4: 948-52 (2013) Article DOI: 10.1021/ml400206q BindingDB Entry DOI: 10.7270/Q28P61Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319791 ((4'-chloro-2-methoxy-2'-methylbiphenyl-4-yl)((1S,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50023737 (6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]-Spiperone | J Med Chem 31: 1392-6 (1988) BindingDB Entry DOI: 10.7270/Q2WW7GP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319784 ((2''-Methoxy-[1,1',2',1'']terphenyl-4''-yl)-((1S,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM84636 (CHEMBL27559 | NPA-11-OH-R,(+)) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]-Spiperone | J Med Chem 31: 1392-6 (1988) BindingDB Entry DOI: 10.7270/Q2WW7GP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50319785 ((5'-chloro-2-methoxy-2'-methylbiphenyl-4-yl)((1S,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor | Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B2 bradykinin receptor (Homo sapiens (Human)) | BDBM50409528 (CHEMBL2112220) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Medical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cells | J Med Chem 45: 2160-72 (2002) BindingDB Entry DOI: 10.7270/Q2X067SG | |||||||||||
More data for this Ligand-Target Pair |
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