Reaction Details |
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Target | Botulinum neurotoxin type A2 [1-425] |
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Ligand | BDBM23306 |
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Substrate/Competitor | SNAP-25 substrate peptide |
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Meas. Tech. | BoNT/A LC Metalloprotease Activity Assay |
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pH | 7.3±n/a |
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Temperature | 295.15±n/a K |
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Comments | 62% inhibition uM. |
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Citation | Burnett, JC; Opsenica, D; Sriraghavan, K; Panchal, RG; Ruthel, G; Hermone, AR; Nguyen, TL; Kenny, TA; Lane, DJ; McGrath, CF; Schmidt, JJ; Vennerstrom, JL; Gussio, R; Solaja, BA; Bavari, S A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. J Med Chem50:2127-36 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Botulinum neurotoxin type A2 [1-425] |
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Name: | Botulinum neurotoxin type A2 [1-425] |
Synonyms: | BXA2_CLOBJ | BoNT/A LC | Botulinum Neurotoxin Type A | Botulinum neurotoxin A light chain | atx | bna | bonT | bont/a2 | botA |
Type: | Metalloprotease |
Mol. Mass.: | 48687.43 |
Organism: | Clostridium botulinum |
Description: | Recombinant C. botulinum LC/A (1-425) was expressed in E. coli. |
Residue: | 425 |
Sequence: | MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGY
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKA
KSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKV
INRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
GLFEF
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BDBM23306 |
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SNAP-25 substrate peptide |
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Name: | SNAP-25 substrate peptide |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 3661.13 |
Organism: | n/a |
Description: | The substrate peptide consisted of residues 187-203 of synaptosomes associated protein (SNAP-25). |
Residue: | 32 |
Sequence: | (N-acetyl)-SNKTRIDEANQRATKML-(carboxamide)
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