| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
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| Ligand | BDBM23842 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Reporter Gene Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 3100±n/a nM |
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| Citation |  Dodo, K; Aoyama, A; Noguchi-Yachide, T; Makishima, M; Miyachi, H; Hashimoto, Y Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem16:4272-85 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-alpha |
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| Name: | Oxysterols receptor LXR-alpha |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50403.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13133 |
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| Residue: | 447 |
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| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM23842 |
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| BDBM10852 |
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| Name | BDBM23842 |
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| Synonyms: | 2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3-dihydro-1H-isoindol-1-one | CHEMBL329471 | PPS-33 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21NOS |
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| Mol. Mass. | 323.452 |
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| SMILES | CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccccc2C1=S |
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| Structure | 
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