Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase 10 |
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Ligand | BDBM24947 |
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Substrate/Competitor | myelin basic protein |
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Meas. Tech. | Mixed-Lineage Kinase Assay |
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pH | 7.2±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 1582±46 nM |
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Citation | Hudkins, RL; Diebold, JL; Tao, M; Josef, KA; Park, CH; Angeles, TS; Aimone, LD; Husten, J; Ator, MA; Meyer, SL; Holskin, BP; Durkin, JT; Fedorov, AA; Fedorov, EV; Almo, SC; Mathiasen, JR; Bozyczko-Coyne, D; Saporito, MS; Scott, RW; Mallamo, JP Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. J Med Chem51:5680-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Mitogen-activated protein kinase kinase kinase 10 |
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Name: | Mitogen-activated protein kinase kinase kinase 10 |
Synonyms: | M3K10_HUMAN | MAP3K10 | MLK2 | MST | Mitogen-activated protein kinase kinase kinase 10 | Mixed Lineage Kinase 2 (MLK2) |
Type: | PROTEIN |
Mol. Mass.: | 103699.30 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1460564 |
Residue: | 954 |
Sequence: | MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
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BDBM24947 |
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myelin basic protein |
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Name: | myelin basic protein |
Synonyms: | MBP | MBP_HUMAN | Myelin A1 protein | Myelin membrane encephalitogenic protein | biotin-MBP protein | biotin-myelin basic protein |
Type: | Other Protein Type |
Mol. Mass.: | 33133.33 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 304 |
Sequence: | MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ
DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI
QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG
GDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG
RGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSP
MARR
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