| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM25287 |
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| Substrate/Competitor | BDBM25257 |
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| Meas. Tech. | GGPP Synthase Inhibition Assay |
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| IC50 | 3240±n/a nM |
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| Citation |  K-M Chen, C; Hudock, MP; Zhang, Y; Guo, RT; Cao, R; No, JH; Liang, PH; Ko, TP; Chang, TH; Chang, SC; Song, Y; Axelson, J; Kumar, A; Wang, AH; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem51:5594-607 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM25287 |
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| BDBM25257 |
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| Name | BDBM25287 |
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| Synonyms: | CHEMBL235690 | bisphosphonate, 37 | hydrogen {2-[methyl(octyl)sulfanylium]-1-phosphonoethyl}phosphonate |
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| Type | Small organic molecule |
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| Emp. Form. | C11H26O6P2S |
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| Mol. Mass. | 348.333 |
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| SMILES | CCCCCCCC[S+](C)CC(P(O)(O)=O)P(O)([O-])=O |
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| Structure | 
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