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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Macrophage colony-stimulating factor 1 receptor | ||
| Ligand | BDBM384222 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro CSF-1R Kinase Activity | ||
| IC50 | <100±n/a nM | ||
| Citation |  Friedman, MM; Cox, P; Frank, KE; Hoemann, MZ; Osuma, A; Wilson, NS; Xu, X; Cusack, K; Huntley, R; Herold, JM Heterocyclic kinase inhibitors US Patent US10280184 Publication Date 5/7/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Macrophage colony-stimulating factor 1 receptor | |||
| Name: | Macrophage colony-stimulating factor 1 receptor | ||
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS | ||
| Type: | Protein | ||
| Mol. Mass.: | 107979.48 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07333 | ||
| Residue: | 972 | ||
| Sequence: |
| ||
| BDBM384222 | |||
| n/a | |||
| Name | BDBM384222 | ||
| Synonyms: | US10280184, Example A.1.6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H27N7O | ||
| Mol. Mass. | 381.4747 | ||
| SMILES | O[C@H]1CC[C@H](CC1)n1cc(Nc2nc(cn3ncnc23)C2CCCCC2)cn1 |r,wU:4.7,1.0,(6.78,-3.57,;5.24,-3.57,;4.47,-4.9,;2.93,-4.9,;2.16,-3.57,;2.93,-2.23,;4.47,-2.23,;.62,-3.57,;-.28,-2.32,;-1.75,-2.8,;-3.08,-2.03,;-3.08,-.49,;-1.75,.28,;-1.75,1.82,;-3.08,2.59,;-4.41,1.82,;-5.88,2.3,;-6.78,1.05,;-5.88,-.19,;-4.41,.28,;-.41,2.59,;.92,1.82,;2.25,2.59,;2.25,4.13,;.92,4.9,;-.41,4.13,;-1.75,-4.34,;-.28,-4.81,)| | ||
| Structure | 
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