Reaction Details |
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Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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Ligand | BDBM26459 |
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Substrate/Competitor | BDBM26431 |
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Meas. Tech. | MurD Inhibition Assay |
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IC50 | >2000000±n/a nM |
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Citation | Humljan, J; Kotnik, M; Contreras-Martel, C; Blanot, D; Urleb, U; Dessen, A; Solmajer, T; Gobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem51:7486-94 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
Synonyms: | D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD |
Type: | Ligase |
Mol. Mass.: | 46963.02 |
Organism: | Escherichia coli (strain K12) |
Description: | n/a |
Residue: | 438 |
Sequence: | MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
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BDBM26459 |
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BDBM26431 |
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Name | BDBM26459 |
Synonyms: | 1,5-dimethyl (2R)-2-[(6-butoxynaphthalene-2-)sulfonamido]pentanedioate | naphthylsulfonamide, 16c |
Type | Small organic molecule |
Emp. Form. | C21H27NO7S |
Mol. Mass. | 437.507 |
SMILES | CCCCOc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H](CCC(=O)OC)C(=O)OC |r| |
Structure |
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