Reaction Details |
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Target | Oxysterols receptor LXR-beta |
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Ligand | BDBM27170 |
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Substrate/Competitor | biotinylated SRC-1 peptide |
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Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Ligand Sensing Assay (LiSA) |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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EC50 | 23±n/a nM |
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Comments | 78% efficacy. |
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Citation | Washburn, DG; Hoang, TH; Campobasso, N; Smallwood, A; Parks, DJ; Webb, CL; Frank, KA; Nord, M; Duraiswami, C; Evans, C; Jaye, M; Thompson, SK Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg Med Chem Lett19:1097-100 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Oxysterols receptor LXR-beta |
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Name: | Oxysterols receptor LXR-beta |
Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50978.79 |
Organism: | Homo sapiens (Human) |
Description: | P55055 |
Residue: | 460 |
Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM27170 |
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biotinylated SRC-1 peptide |
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Name: | biotinylated SRC-1 peptide |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 3157.52 |
Organism: | n/a |
Description: | A biotinylated peptide comprises amino acids 675-699 of steroid receptor coactivator 1 (SRC1). |
Residue: | 28 |
Sequence: | CPSSHSSLTERHKILHRLLQEGSPS-CONH2
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