Reaction Details |
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Target | cAMP-dependent protein kinase catalytic subunit alpha |
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Ligand | BDBM27236 |
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Substrate/Competitor | BDBM27221 |
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Meas. Tech. | Fluorescence Polarization-Based Binding Displacement Kinase Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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Kd | 1640±310 nM |
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Citation | Lavogina, D; Lust, M; Viil, I; König, N; Raidaru, G; Rogozina, J; Enkvist, E; Uri, A; Bossemeyer, D Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J Med Chem52:308-21 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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cAMP-dependent protein kinase catalytic subunit alpha |
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Name: | cAMP-dependent protein kinase catalytic subunit alpha |
Synonyms: | KAPCA_MOUSE | PKA C-alpha | Pkaca | Prkaca | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase, alpha-catalytic subunit |
Type: | Enzyme Catalytic Unit |
Mol. Mass.: | 40579.18 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 351 |
Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
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BDBM27236 |
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BDBM27221 |
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Name | BDBM27236 |
Synonyms: | 6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-(4-aminobutyl)hexanamide | ARC-1008, 10 |
Type | Small organic molecule |
Emp. Form. | C20H32N8O5 |
Mol. Mass. | 464.5187 |
SMILES | NCCCCNC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| |
Structure |
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