Ki Summary

Reaction Details

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Target

cAMP-dependent protein kinase catalytic subunit alpha

Ligand

BDBM27240

Substrate/Competitor

BDBM27221

Meas. Tech.

Fluorescence Polarization-Based Binding Displacement Kinase Assay

7.5±n/a

Temperature

303.15±n/a K

1960±320 nM

Citation

Lavogina, D; Lust, M; Viil, I; König, N; Raidaru, G; Rogozina, J; Enkvist, E; Uri, A; Bossemeyer, D Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J Med Chem52:308-21 (2009) [PubMed] Article

More Info.:

Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

cAMP-dependent protein kinase catalytic subunit alpha

Name:

cAMP-dependent protein kinase catalytic subunit alpha

Synonyms:

Type:

Enzyme Catalytic Unit

Mol. Mass.:

40579.18

Organism:

Mus musculus (mouse)

Description:

n/a

Residue:

351

Sequence:

MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF

BDBM27240

BDBM27221

Name

BDBM27240

Synonyms:

6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-2-(4-benzoylphenyl)-1-carbamoylethyl]hexanamide | ARC-1014, 14

Type

Small organic molecule

Emp. Form.

C32H36N8O7

Mol. Mass.

644.6776

SMILES

NC(=O)[C@@H](Cc1ccc(cc1)C(=O)c1ccccc1)NC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|

Structure