Reaction Details |
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Target | Glycogen phosphorylase, liver form |
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Ligand | BDBM27745 |
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Substrate/Competitor | BDBM24362 |
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Meas. Tech. | Human Liver GPa Enzymatic Activity Assay |
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pH | 7.6±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 4±1 nM |
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Citation | Thomson, SA; Banker, P; Bickett, DM; Boucheron, JA; Carter, HL; Clancy, DC; Cooper, JP; Dickerson, SH; Garrido, DM; Nolte, RT; Peat, AJ; Sheckler, LR; Sparks, SM; Tavares, FX; Wang, L; Wang, TY; Weiel, JE Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg Med Chem Lett19:1177-82 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Glycogen phosphorylase, liver form |
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Name: | Glycogen phosphorylase, liver form |
Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
Type: | Homodimer |
Mol. Mass.: | 97153.98 |
Organism: | Homo sapiens (Human) |
Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
Residue: | 847 |
Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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BDBM27745 |
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BDBM24362 |
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Name | BDBM27745 |
Synonyms: | (2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-propylphenyl)carbamoyl]amino}-4-(4-methoxyphenyl)phenyl)formamido]butanoic acid | anthranilimide based compound, 21 |
Type | Small organic molecule |
Emp. Form. | C34H43N3O6 |
Mol. Mass. | 589.7217 |
SMILES | CCCc1cc(C)c(NC(=O)Nc2cc(ccc2C(=O)N[C@@H]([C@@H](C)OC(C)(C)C)C(O)=O)-c2ccc(OC)cc2)c(C)c1 |r| |
Structure |
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