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TargetHigh affinity nerve growth factor receptor [440-796]
LigandBDBM27895
Substrate/CompetitorpolyGlu4Tyr
Meas. Tech.TrkA Enzyme Inhibition Assay
Temperature298.15±n/a K
IC50>500±n/a nM
Commentsextracted
Citation Huang, H; Hutta, DA; Rinker, JM; Hu, H; Parsons, WH; Schubert, C; Desjarlais, RL; Crysler, CS; Chaikin, MA; Donatelli, RR; Chen, Y; Cheng, D; Zhou, Z; Yurkow, E; Manthey, CL; Player, MR Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (dagger). J Med Chem52:1081-99 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
High affinity nerve growth factor receptor [440-796]
Name:High affinity nerve growth factor receptor [440-796]
Synonyms:High affinity nerve growth factor receptor | MTC | NTRK1 | NTRK1_HUMAN | Neurotrophic tyrosine kinase receptor type 1 | TRK | TRK1-transforming tyrosine kinase protein | TRKA | Tyrosine Kinase TrkA | p140-TrkA
Type:Cytoplasmic region
Mol. Mass.:40053.30
Organism:Homo sapiens (Human)
Description:The histidine-tagged recombinant human TrkA cytoplasmic domain (amino acids 440-796) expressed in insect cells was used in enzyme assays.
Residue:357
Sequence:
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSD
ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP
GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD
YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC
ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27895
polyGlu4Tyr
Name:polyGlu4Tyr
Synonyms:n/a
Type:Random copolymer
Mol. Mass.:358.43
Organism:n/a
Description:n/a
Residue:3
Sequence:
n/a