Reaction Details |
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Target | Serine/threonine-protein kinase pim-1 |
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Ligand | BDBM28397 |
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Substrate/Competitor | PIM peptide substrate |
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Meas. Tech. | Pim Kinase Dose-Response Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 13±0.5 nM |
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Citation | Qian, K; Wang, L; Cywin, CL; Farmer, BT; Hickey, E; Homon, C; Jakes, S; Kashem, MA; Lee, G; Leonard, S; Li, J; Magboo, R; Mao, W; Pack, E; Peng, C; Prokopowicz, A; Welzel, M; Wolak, J; Morwick, T Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J Med Chem52:1814-27 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Serine/threonine-protein kinase pim-1 |
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Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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BDBM28397 |
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PIM peptide substrate |
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Name: | PIM peptide substrate |
Synonyms: | n/a |
Type: | Biotinylated peptide |
Mol. Mass.: | 1402.69 |
Organism: | n/a |
Description: | n/a |
Residue: | 12 |
Sequence: | |