Reaction Details |
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Target | Renin |
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Ligand | BDBM29940 |
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Substrate/Competitor | Renin Substrate |
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Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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pH | 7±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 21±n/a nM |
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Citation | Tice, CM; Xu, Z; Yuan, J; Simpson, RD; Cacatian, ST; Flaherty, PT; Zhao, W; Guo, J; Ishchenko, A; Singh, SB; Wu, Z; Scott, BB; Bukhtiyarov, Y; Berbaum, J; Mason, J; Panemangalore, R; Cappiello, MG; Müller, D; Harrison, RK; McGeehan, GM; Dillard, LW; Baldwin, JJ; Claremon, DA Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg Med Chem Lett19:3541-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM29940 |
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Renin Substrate |
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Name: | Renin Substrate |
Synonyms: | n/a |
Type: | FRET peptide substrate |
Mol. Mass.: | 4889.99 |
Organism: | n/a |
Description: | n/a |
Residue: | 44 |
Sequence: | DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDA
NS
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