| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM17950 |
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| Substrate/Competitor | Renin Substrate |
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| Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.5±n/a nM |
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| Comments | extracted |
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| Citation |  Tice, CM; Xu, Z; Yuan, J; Simpson, RD; Cacatian, ST; Flaherty, PT; Zhao, W; Guo, J; Ishchenko, A; Singh, SB; Wu, Z; Scott, BB; Bukhtiyarov, Y; Berbaum, J; Mason, J; Panemangalore, R; Cappiello, MG; Müller, D; Harrison, RK; McGeehan, GM; Dillard, LW; Baldwin, JJ; Claremon, DA Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg Med Chem Lett19:3541-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM17950 |
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| Renin Substrate |
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| Name: | Renin Substrate |
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| Synonyms: | n/a |
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| Type: | FRET peptide substrate |
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| Mol. Mass.: | 4889.99 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 44 |
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| Sequence: | DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDA
NS
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