Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM31285 |
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Substrate/Competitor | Fl 9mer |
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Meas. Tech. | Fluorescent Peptide Displacement Assay |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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Kd | 80±n/a nM |
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Citation | Grasberger, BL; Lu, T; Schubert, C; Parks, DJ; Carver, TE; Koblish, HK; Cummings, MD; LaFrance, LV; Milkiewicz, KL; Calvo, RR; Maguire, D; Lattanze, J; Franks, CF; Zhao, S; Ramachandren, K; Bylebyl, GR; Zhang, M; Manthey, CL; Petrella, EC; Pantoliano, MW; Deckman, IC; Spurlino, JC; Maroney, AC; Tomczuk, BE; Molloy, CJ; Bone, RF Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem48:909-12 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM31285 |
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Fl 9mer |
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Name: | Fl 9mer |
Synonyms: | n/a |
Type: | fluorescent peptide |
Mol. Mass.: | 2263.48 |
Organism: | n/a |
Description: | n/a |
Residue: | 18 |
Sequence: | |