| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S] |
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| Ligand | BDBM32534 |
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| Substrate/Competitor | BDBM13739 |
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| Meas. Tech. | Human 11beta-HSD1 SPA Assay |
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| pH | 7.2±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 20±n/a nM |
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| EC50 | 574±n/a nM |
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| Citation |  Sun, D; Wang, Z; Di, Y; Jaen, JC; Labelle, M; Ma, J; Miao, S; Sudom, A; Tang, L; Tomooka, CS; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett18:3513-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S] |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S] |
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| Synonyms: | 11-DH | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Homodimer |
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| Mol. Mass.: | 31804.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified recombinant human 11beta-HSD1. |
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| Residue: | 286 |
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| Sequence: | MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTAR
SKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL
NLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSAS
KFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEII
KGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK
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| BDBM32534 |
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| BDBM13739 |
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| Name | BDBM32534 |
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| Synonyms: | arylsulfonylpiperazine, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18F3N3O2S |
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| Mol. Mass. | 385.404 |
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| SMILES | FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)Cc1ccccc1 |
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| Structure | 
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