| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
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| Ligand | BDBM35167 |
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| Substrate/Competitor | Histone type 3 |
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| Meas. Tech. | PKC Enzyme Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 4.1±n/a nM |
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| Comments | extracted |
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| Citation |  Trujillo, JI; Kiefer, JR; Huang, W; Thorarensen, A; Xing, L; Caspers, NL; Day, JE; Mathis, KJ; Kretzmer, KK; Reitz, BA; Weinberg, RA; Stegeman, RA; Wrightstone, A; Christine, L; Compton, R; Li, X 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett19:908-11 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
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| Name: | Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| Component 2 |
| Name: | Cyclin-A2 [177-432] |
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| Synonyms: | CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A |
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| Type: | Subunit of Enzyme Complex |
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| Mol. Mass.: | 29394.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20248[177-432] |
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| Residue: | 256 |
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| Sequence: | DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAV
NYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEH
LVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIA
GAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNS
KYHGVSLLNPPETLNL
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| BDBM35167 |
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| Histone type 3 |
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| Name: | Histone type 3 |
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| Synonyms: | n/a |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 358.43 |
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| Organism: | Bos taurus (bovine) |
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| Description: | It is an isolated lysine rich fraction. |
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| Residue: | 3 |
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| Sequence: | |
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