Reaction Details |
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Target | Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
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Ligand | BDBM35186 |
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Substrate/Competitor | Histone type 3 |
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Meas. Tech. | PKC Enzyme Assay |
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Temperature | 298.15±n/a K |
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IC50 | 10000±n/a nM |
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Comments | extracted |
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Citation | Trujillo, JI; Kiefer, JR; Huang, W; Thorarensen, A; Xing, L; Caspers, NL; Day, JE; Mathis, KJ; Kretzmer, KK; Reitz, BA; Weinberg, RA; Stegeman, RA; Wrightstone, A; Christine, L; Compton, R; Li, X 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett19:908-11 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
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Name: | Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 |
Synonyms: | CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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Component 2 |
Name: | Cyclin-A2 [177-432] |
Synonyms: | CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A |
Type: | Subunit of Enzyme Complex |
Mol. Mass.: | 29394.24 |
Organism: | Homo sapiens (Human) |
Description: | P20248[177-432] |
Residue: | 256 |
Sequence: | DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAV
NYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEH
LVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIA
GAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNS
KYHGVSLLNPPETLNL
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BDBM35186 |
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Histone type 3 |
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Name: | Histone type 3 |
Synonyms: | n/a |
Type: | Other Protein Type |
Mol. Mass.: | 358.43 |
Organism: | Bos taurus (bovine) |
Description: | It is an isolated lysine rich fraction. |
Residue: | 3 |
Sequence: | |