Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM185309 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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IC50 | 33.0±n/a nM |
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Citation | Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS 1,2-substituted cyclopentanes as orexin receptor antagonists US Patent US10011588 Publication Date 7/3/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM185309 |
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n/a |
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Name | BDBM185309 |
Synonyms: | US10011588, Example 129 | US10689373, Example 129 | US9156829, 128 | US9156829, 129 |
Type | Small organic molecule |
Emp. Form. | C20H17F5N6O |
Mol. Mass. | 452.3806 |
SMILES | FC(F)(F)c1ccc(NC2CC(F)(F)CC2NC(=O)c2ccccc2-n2nccn2)nc1 |
Structure |
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