| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM185319 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Assay |
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| IC50 | 35.0±n/a nM |
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| Citation |  Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS 1,2-substituted cyclopentanes as orexin receptor antagonists US Patent US10011588 Publication Date 7/3/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM185319 |
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| n/a |
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| Name | BDBM185319 |
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| Synonyms: | US10011588, Example 140 | US10689373, Example 140 | US9156829, 140 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F4N5O2 |
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| Mol. Mass. | 449.4015 |
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| SMILES | Cc1noc(n1)-c1ccccc1C(=O)N[C@H]1CCC[C@@H]1Nc1ncc(cc1F)C(F)(F)F |r| |
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| Structure | 
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