Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM36516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Btk Kinase Assay |
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pH | 7.5±0 |
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Temperature | 296.15±0 K |
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IC50 | 1.9±0.4 nM |
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Kd | 1.5±n/a nM |
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Citation | Di Paolo, JA; Huang, T; Balazs, M; Barbosa, J; Barck, KH; Bravo, BJ; Carano, RA; Darrow, J; Davies, DR; DeForge, LE; Diehl, L; Ferrando, R; Gallion, SL; Giannetti, AM; Gribling, P; Hurez, V; Hymowitz, SG; Jones, R; Kropf, JE; Lee, WP; Maciejewski, PM; Mitchell, SA; Rong, H; Staker, BL; Whitney, JA; Yeh, S; Young, WB; Yu, C; Zhang, J; Reif, K; Currie, KS Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat Chem Biol7:41-50 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM36516 |
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n/a |
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Name | BDBM36516 |
Synonyms: | 4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide | CGI1746, 2 |
Type | Small organic molecule |
Emp. Form. | C34H37N5O4 |
Mol. Mass. | 579.6887 |
SMILES | Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCOCC2)n1 |
Structure |
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