Compile Data Set for Download or QSAR

Found 100 hits with Last Name = 'maciejewski' and Initial = 'pm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM36516 (4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...) Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCOCC2)n1 Show InChI InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	1.5	n/a	n/a	n/a	7.5	23
CGI Pharmaceuticals					Assay Description Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.				Nat Chem Biol 7: 41-50 (2011) Article DOI: 10.1038/nchembio.481 BindingDB Entry DOI: 10.7270/Q2B56H2T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EPHA2 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312184 (1-(2-hydroxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES Oc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H20F3N7O2/c27-26(28,29)18-4-5-22(37)20(13-18)35-25(38)33-19-3-1-2-17(12-19)21-15-36-11-10-31-24(36)23(34-21)32-14-16-6-8-30-9-7-16/h1-13,15,37H,14H2,(H,32,34)(H2,33,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312187 (1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H19ClF3N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312200 (1-(3-(8-(methyl(pyridin-4-ylmethyl)amino)imidazo[1...) Show SMILES CN(Cc1ccncc1)c1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1 Show InChI InChI=1S/C27H22F3N7O/c1-36(16-18-8-10-31-11-9-18)25-24-32-12-13-37(24)17-23(35-25)19-4-2-6-21(14-19)33-26(38)34-22-7-3-5-20(15-22)27(28,29)30/h2-15,17H,16H2,1H3,(H2,33,34,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR3 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312178 (1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(pyridin-4-yl...) Show SMILES COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22ClN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312175 (1-(2-methoxy-5-methylphenyl)-3-(3-(8-(pyridin-4-yl...) Show SMILES COc1ccc(C)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C27H25N7O2/c1-18-6-7-24(36-2)22(14-18)33-27(35)31-21-5-3-4-20(15-21)23-17-34-13-12-29-26(34)25(32-23)30-16-19-8-10-28-11-9-19/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312155 (1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312185 (1-(2,5-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...) Show SMILES Clc1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C25H19Cl2N7O/c26-18-4-5-20(27)21(13-18)33-25(35)31-19-3-1-2-17(12-19)22-15-34-11-10-29-24(34)23(32-22)30-14-16-6-8-28-9-7-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312201 (1-(3-(8-(pyridin-4-ylmethoxy)imidazo[1,2-a]pyrazin...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(OCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H19F3N6O2/c27-26(28,29)19-4-2-6-21(14-19)33-25(36)32-20-5-1-3-18(13-20)22-15-35-12-11-31-23(35)24(34-22)37-16-17-7-9-30-10-8-17/h1-15H,16H2,(H2,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312174 (1-(5-cyano-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C#N Show InChI InChI=1S/C27H22N8O2/c1-37-24-6-5-19(15-28)13-22(24)34-27(36)32-21-4-2-3-20(14-21)23-17-35-12-11-30-26(35)25(33-23)31-16-18-7-9-29-10-8-18/h2-14,17H,16H2,1H3,(H,31,33)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312177 (1-(5-chloro-2-phenoxyphenyl)-3-(3-(8-(pyridin-4-yl...) Show SMILES Clc1ccc(Oc2ccccc2)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C31H24ClN7O2/c32-23-9-10-28(41-25-7-2-1-3-8-25)26(18-23)38-31(40)36-24-6-4-5-22(17-24)27-20-39-16-15-34-30(39)29(37-27)35-19-21-11-13-33-14-12-21/h1-18,20H,19H2,(H,35,37)(H2,36,38,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312203 (1-(3-(8-(2-(pyridin-4-yl)ethylamino)imidazo[1,2-a]...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCCc3ccncc3)n2)c1 Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)20-4-2-6-22(16-20)35-26(38)34-21-5-1-3-19(15-21)23-17-37-14-13-33-25(37)24(36-23)32-12-9-18-7-10-31-11-8-18/h1-8,10-11,13-17H,9,12H2,(H,32,36)(H2,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312176 (1-(5-chloro-2-methylphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES Cc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22ClN7O/c1-17-5-6-20(27)14-22(17)33-26(35)31-21-4-2-3-19(13-21)23-16-34-12-11-29-25(34)24(32-23)30-15-18-7-9-28-10-8-18/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312197 (1-(3-chlorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...) Show SMILES Clc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C25H20ClN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312169 (1-(5-bromo-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-4...) Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Br Show InChI InChI=1S/C27H24BrN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312167 (1-(2,4-diethoxy-5-(trifluoromethyl)phenyl)-3-(3-(8...) Show SMILES CCOc1cc(OCC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C30H28F3N7O3/c1-3-42-25-16-26(43-4-2)23(15-22(25)30(31,32)33)39-29(41)37-21-7-5-6-20(14-21)24-18-40-13-12-35-28(40)27(38-24)36-17-19-8-10-34-11-9-19/h5-16,18H,3-4,17H2,1-2H3,(H,36,38)(H2,37,39,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	211	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312196 (1-(3-bromophenyl)-3-(3-(8-(pyridin-4-ylmethylamino...) Show SMILES Brc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C25H20BrN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	213	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50312157 (1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...) Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312195 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H23N7O/c1-18-4-2-6-21(14-18)30-26(34)31-22-7-3-5-20(15-22)23-17-33-13-12-28-25(33)24(32-23)29-16-19-8-10-27-11-9-19/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312156 (1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312170 (1-(5-chloro-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-...) Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl Show InChI InChI=1S/C27H24ClN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	402	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312166 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES Clc1cc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl Show InChI InChI=1S/C25H18Cl3N7O/c26-18-11-20(28)21(12-19(18)27)34-25(36)32-17-3-1-2-16(10-17)22-14-35-9-8-30-24(35)23(33-22)31-13-15-4-6-29-7-5-15/h1-12,14H,13H2,(H,31,33)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	517	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312168 (1-(2,4-dimethoxy-5-(trifluoromethyl)phenyl)-3-(3-(...) Show SMILES COc1cc(OC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F Show InChI InChI=1S/C28H24F3N7O3/c1-40-23-14-24(41-2)21(13-20(23)28(29,30)31)37-27(39)35-19-5-3-4-18(12-19)22-16-38-11-10-33-26(38)25(36-22)34-15-17-6-8-32-9-7-17/h3-14,16H,15H2,1-2H3,(H,34,36)(H2,35,37,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	518	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM36521 (6-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...) Show SMILES Cc1c(NC(=O)c2ccc(nc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCOCC2)n1 Show InChI InChI=1S/C33H36N6O4/c1-21-25(7-6-8-26(21)37-30(40)23-11-14-28(34-19-23)33(2,3)4)27-20-38(5)32(42)29(36-27)35-24-12-9-22(10-13-24)31(41)39-15-17-43-18-16-39/h6-14,19-20H,15-18H2,1-5H3,(H,35,36)(H,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	7.5	23
CGI Pharmaceuticals					Assay Description Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.				Nat Chem Biol 7: 41-50 (2011) Article DOI: 10.1038/nchembio.481 BindingDB Entry DOI: 10.7270/Q2B56H2T
					More data for this Ligand-Target Pair				3D Structure (docked)
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312165 (CHEMBL1079795 | N-(3-(8-(pyridin-4-ylmethylamino)i...) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C26H19F3N6O/c27-26(28,29)20-5-1-4-19(13-20)25(36)33-21-6-2-3-18(14-21)22-16-35-12-11-31-24(35)23(34-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,34)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	744	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50312153 (1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	747	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR1 after 1 hr				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312173 (1-(4-methyl-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F Show InChI InChI=1S/C27H22F3N7O/c1-17-5-6-21(14-22(17)27(28,29)30)35-26(38)34-20-4-2-3-19(13-20)23-16-37-12-11-32-25(37)24(36-23)33-15-18-7-9-31-10-8-18/h2-14,16H,15H2,1H3,(H,33,36)(H2,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312172 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...) Show SMILES Fc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F Show InChI InChI=1S/C26H19F4N7O/c27-21-5-4-19(13-20(21)26(28,29)30)35-25(38)34-18-3-1-2-17(12-18)22-15-37-11-10-32-24(37)23(36-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,36)(H2,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312186 (1-(2,5-dimethylphenyl)-3-(3-(8-(pyridin-4-ylmethyl...) Show SMILES Cc1ccc(C)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1 Show InChI InChI=1S/C27H25N7O/c1-18-6-7-19(2)23(14-18)33-27(35)31-22-5-3-4-21(15-22)24-17-34-13-12-29-26(34)25(32-24)30-16-20-8-10-28-11-9-20/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	938	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50312179 (1-(2,6-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...) Show SMILES Clc1cccc(Cl)c1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1 Show InChI InChI=1S/C25H19Cl2N7O/c26-19-5-2-6-20(27)22(19)33-25(35)31-18-4-1-3-17(13-18)21-15-34-12-11-29-24(34)23(32-21)30-14-16-7-9-28-10-8-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CGI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation by cell based assay				Bioorg Med Chem Lett 19: 6991-5 (2009) Article DOI: 10.1016/j.bmcl.2009.10.037 BindingDB Entry DOI: 10.7270/Q2DR2VM3
					More data for this Ligand-Target Pair

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