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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase ATR | ||
| Ligand | BDBM268225 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer (TR-FRET Tracer A) | ||
| pH | 7±n/a | ||
| IC50 | 7.66±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wortmann, L; Lücking, U; Lefranc, J; Briem, H; Von Nussbaum, F; Bader, B; Siemeister, G; Bone, W; Lienau, P; Moosmayer, D; Eberspächer, U; Schick, H; Eis, K; Koppitz, M; Wengner, AM; Grudzinska-Goebel, J 2-(morpholin-4-yl)-1,7-naphthyridines US Patent US9549932 Publication Date 1/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase ATR | |||
| Name: | Serine/threonine-protein kinase ATR | ||
| Synonyms: | ATR | ATR_HUMAN | Ataxia telangiectasia and Rad3-related protein (ATR) | FRAP-related protein 1 | FRP1 | Serine-protein kinase ATR | ||
| Type: | Protein | ||
| Mol. Mass.: | 301404.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13535 | ||
| Residue: | 2644 | ||
| Sequence: |
| ||
| BDBM268225 | |||
| n/a | |||
| Name | BDBM268225 | ||
| Synonyms: | US10772893, Example 258 | US11529356, Example 258 | US9549932, 258 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25N7O | ||
| Mol. Mass. | 403.4802 | ||
| SMILES | C[C@@H]1COCCN1c1cc(-c2c(C)nn(C)c2C)c2ccnc(-c3ccn[nH]3)c2n1 |r,wU:1.0,(-.67,4.52,;-2,3.75,;-3.33,4.52,;-4.67,3.75,;-4.67,2.21,;-3.33,1.44,;-2,2.21,;-.67,1.44,;-.67,-.1,;.67,-.87,;.67,-2.41,;-.58,-3.32,;-1.91,-2.55,;-.1,-4.78,;1.44,-4.78,;2.21,-6.12,;1.91,-3.32,;3.25,-2.55,;2,-.1,;3.33,-.87,;4.67,-.1,;4.67,1.44,;3.33,2.21,;3.33,3.75,;2.09,4.65,;2.56,6.12,;4.1,6.12,;4.58,4.65,;2,1.44,;.67,2.21,)| | ||
| Structure | 
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