Compile Data Set for Download or QSAR

Found 2637 hits with Last Name = 'lefranc' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50520160 (CHEMBL4515413 | US10894784, Example 01.03) Show SMILES Cc1cc(ccn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 Show InChI InChI=1S/C26H26F3N7O/c1-17-12-20(5-7-30-17)19-2-3-21-22(14-19)33-25(32-21)34-23-13-18(4-6-31-23)16-35-8-10-36(11-9-35)24(37)15-26(27,28)29/h2-7,12-14H,8-11,15-16H2,1H3,(H2,31,32,33,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...				J Med Chem 63: 601-612 (2020) Article DOI: 10.1021/acs.jmedchem.9b01460 BindingDB Entry DOI: 10.7270/Q2CN7795
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478724 (US10894784, Example 117.02 | cyclopropyl(4-{(1R or...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478844 (US10894784, Example 117.05) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 |w:11.11| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.473	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478804 (US10894784, Example 152.02) Show SMILES FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cc(NC4CCC4)ncn3)c2)CC1 Show InChI InChI=1S/C28H30F3N9O/c29-28(30,31)15-26(41)40-10-8-39(9-11-40)16-18-6-7-32-24(12-18)38-27-36-21-5-4-19(13-23(21)37-27)22-14-25(34-17-33-22)35-20-2-1-3-20/h4-7,12-14,17,20H,1-3,8-11,15-16H2,(H,33,34,35)(H2,32,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478725 (3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(pyrr...) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478853 (US10894784, Example 164.03) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.558	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478542 (US10894784, Example 55.03 | cyclopropyl{4-[(1R or ...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 |w:33.36| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.564	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478855 (US10894784, Example 164.05) Show SMILES CC(N1CCN(CC1)C(=O)[C@@H]1CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.566	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478573 (US10894784, Example 55.03.01 | US10894784, Example...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478719 ((4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimidi...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478581 (1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-chlorocyclopropyl...) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3(Cl)CC3)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478573 (US10894784, Example 55.03.01 | US10894784, Example...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM50520150 (CHEMBL4566796) Show SMILES COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)[C@@H](C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1 |r| Show InChI InChI=1S/C27H29F3N8O2/c1-17(37-7-9-38(10-8-37)25(39)14-27(28,29)30)18-5-6-31-24(12-18)36-26-34-21-4-3-19(11-23(21)35-26)22-13-20(15-40-2)32-16-33-22/h3-6,11-13,16-17H,7-10,14-15H2,1-2H3,(H2,31,34,35,36)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...				J Med Chem 63: 601-612 (2020) Article DOI: 10.1021/acs.jmedchem.9b01460 BindingDB Entry DOI: 10.7270/Q2CN7795
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478614 (3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(meth...) Show SMILES COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478571 (1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1R or IS)-2,2-difl...) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478583 (US10894784, Example 70.02 | {4-[(1R or 1S)-1-(2-{[...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5(F)F)c4)c(Cl)c3[nH]2)c1 |w:29.31| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478718 (1-(4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimi...) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478720 (US10894784, Example 116.02 | cyclopropyl(4-{(1R or...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(F)(F)C2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478843 (US10894784, Example 117.04) Show SMILES CC(N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.819	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478854 (US10894784, Example 164.04) Show SMILES CC(N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.832	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478845 (US10894784, Example 117.06) Show SMILES CC(N1CCN(CC1)C(=O)C1(C)CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 |w:10.11| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478594 ((4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylmet...) Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)c(Cl)c3[nH]2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478582 (1-{4-[(1R or 1S)-1-(2-{[7-chloro-6-(1-{[(1RS)-2,2-...) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5(F)F)c4)c(Cl)c3[nH]2)c1 |w:31.32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478852 (US10894784, Example 164.02) Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.943	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478805 (US10894784, Example 152.03) Show SMILES O=C(C1CC1)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cc(NC4CCC4)ncn3)c2)CC1 Show InChI InChI=1S/C29H33N9O/c39-28(20-4-5-20)38-12-10-37(11-13-38)17-19-8-9-30-26(14-19)36-29-34-23-7-6-21(15-25(23)35-29)24-16-27(32-18-31-24)33-22-2-1-3-22/h6-9,14-16,18,20,22H,1-5,10-13,17H2,(H,31,32,33)(H2,30,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420259 (US10487092, Example 107 | [(3S)-3-(Dimethylamino)p...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420251 ((7S)—N-[3-(Dimethylamino)propyl]-4-[(6-methoxypyra...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)CCCN(C)C |r| Show InChI InChI=1S/C25H31N7O2S/c1-30(2)10-5-11-31(3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM478708 ((4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-metho...) Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1)N1CCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...				US Patent US10894784 (2021) BindingDB Entry DOI: 10.7270/Q2PV6PFT
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420271 ((7S)—N,N-Bis(2-methoxyethyl)-4-[(6-methoxypyrazolo...) Show SMILES COCCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C25H30N6O4S/c1-33-10-8-30(9-11-34-2)25(32)16-4-5-18-21(12-16)36-24-22(18)23(26-15-27-24)29-19-13-17-6-7-28-31(17)14-20(19)35-3/h6-7,13-16H,4-5,8-12H2,1-3H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420250 (1-((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)a...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N |r| Show InChI InChI=1S/C23H21N7O2S/c1-32-18-11-30-15(4-5-27-30)7-17(18)28-21-20-16-3-2-14(23(31)29-9-13(8-24)10-29)6-19(16)33-22(20)26-12-25-21/h4-5,7,11-14H,2-3,6,9-10H2,1H3,(H,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420249 ((7S)—N-Butyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...) Show SMILES CCCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C24H28N6O2S/c1-4-5-10-29(2)24(31)15-6-7-17-20(11-15)33-23-21(17)22(25-14-26-23)28-18-12-16-8-9-27-30(16)13-19(18)32-3/h8-9,12-15H,4-7,10-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420246 ((7S)—N-Ethyl-4-[(6-methoxypyrazolo[1,5-a]pyridin-5...) Show SMILES CCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C22H24N6O2S/c1-4-27(2)22(29)13-5-6-15-18(9-13)31-21-19(15)20(23-12-24-21)26-16-10-14-7-8-25-28(14)11-17(16)30-3/h7-8,10-13H,4-6,9H2,1-3H3,(H,23,24,26)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420157 ((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...) Show SMILES CN(C)[C@H]1CCN(C1)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r| Show InChI InChI=1S/C24H26ClN7OS/c1-30(2)16-6-8-31(11-16)24(33)14-3-4-17-20(9-14)34-23-21(17)22(26-13-27-23)29-19-10-15-5-7-28-32(15)12-18(19)25/h5,7,10,12-14,16H,3-4,6,8-9,11H2,1-2H3,(H,26,27,29)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50520159 (CHEMBL4543618) Show SMILES CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc(ccn3)[C@@H](C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1 |r| Show InChI InChI=1S/C28H31F3N8O2/c1-17(2)41-23-15-32-16-34-26(23)20-4-5-21-22(12-20)36-27(35-21)37-24-13-19(6-7-33-24)18(3)38-8-10-39(11-9-38)25(40)14-28(29,30)31/h4-7,12-13,15-18H,8-11,14H2,1-3H3,(H2,33,35,36,37)/t18-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...				J Med Chem 63: 601-612 (2020) Article DOI: 10.1021/acs.jmedchem.9b01460 BindingDB Entry DOI: 10.7270/Q2CN7795
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50520175 (CHEMBL4451595 | US10894784, Example 135.02) Show SMILES CN(C)c1cc(ccn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1 Show InChI InChI=1S/C27H29F3N8O/c1-36(2)24-15-20(6-8-32-24)19-3-4-21-22(14-19)34-26(33-21)35-23-13-18(5-7-31-23)17-37-9-11-38(12-10-37)25(39)16-27(28,29)30/h3-8,13-15H,9-12,16-17H2,1-2H3,(H2,31,33,34,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...				J Med Chem 63: 601-612 (2020) Article DOI: 10.1021/acs.jmedchem.9b01460 BindingDB Entry DOI: 10.7270/Q2CN7795
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420278 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@H]1C |r| Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420277 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C24H26N6O3S/c1-14-12-33-8-7-29(14)24(31)15-3-4-17-20(9-15)34-23-21(17)22(25-13-26-23)28-18-10-16-5-6-27-30(16)11-19(18)32-2/h5-6,10-11,13-15H,3-4,7-9,12H2,1-2H3,(H,25,26,28)/t14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420276 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CO2 |r,THB:25:27:32.33:30| Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15+,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420274 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CN2C |r,THB:34:33:27.28:30,25:27:32.33:30| Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16+,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420273 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CN2C |r,TLB:34:33:28.27:30,25:27:33.32:30| Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420270 ((7S)—N-Ethyl-N-(2-methoxyethyl)-4-[(6-methoxypyraz...) Show SMILES CCN(CCOC)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C24H28N6O3S/c1-4-29(9-10-32-2)24(31)15-5-6-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-7-8-27-30(16)13-19(18)33-3/h7-8,12-15H,4-6,9-11H2,1-3H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420269 ((7S)—N-Ethyl-N-(2-hydroxyethyl)-4-[(6-methoxypyraz...) Show SMILES CCN(CCO)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C23H26N6O3S/c1-3-28(8-9-30)23(31)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-2/h6-7,11-14,30H,3-5,8-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420268 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H24N6O3S/c1-31-18-12-29-15(4-5-26-29)11-17(18)27-21-20-16-3-2-14(23(30)28-6-8-32-9-7-28)10-19(16)33-22(20)25-13-24-21/h4-5,11-14H,2-3,6-10H2,1H3,(H,24,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420267 ((7S)—N-[2-(Dimethylamino)ethyl]-N-ethyl-4-[(6-meth...) Show SMILES CCN(CCN(C)C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r| Show InChI InChI=1S/C25H31N7O2S/c1-5-31(11-10-30(2)3)25(33)16-6-7-18-21(12-16)35-24-22(18)23(26-15-27-24)29-19-13-17-8-9-28-32(17)14-20(19)34-4/h8-9,13-16H,5-7,10-12H2,1-4H3,(H,26,27,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420266 (4-[2-(Dimethylamino)ethyl]piperazin-1-yl(7S)-4-[(6...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(CCN(C)C)CC1 |r| Show InChI InChI=1S/C27H34N8O2S/c1-32(2)8-9-33-10-12-34(13-11-33)27(36)18-4-5-20-23(14-18)38-26-24(20)25(28-17-29-26)31-21-15-19-6-7-30-35(19)16-22(21)37-3/h6-7,15-18H,4-5,8-14H2,1-3H3,(H,28,29,31)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420265 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCN(C)CC1 |r| Show InChI InChI=1S/C24H27N7O2S/c1-29-7-9-30(10-8-29)24(32)15-3-4-17-20(11-15)34-23-21(17)22(25-14-26-23)28-18-12-16-5-6-27-31(16)13-19(18)33-2/h5-6,12-15H,3-4,7-11H2,1-2H3,(H,25,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420262 ((4-[2-Dimethylamino)ethyl]methyl)aminopiperidin-1-...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)CCN(C)C |r| Show InChI InChI=1S/C29H38N8O2S/c1-34(2)13-14-35(3)20-8-11-36(12-9-20)29(38)19-5-6-22-25(15-19)40-28-26(22)27(30-18-31-28)33-23-16-21-7-10-32-37(21)17-24(23)39-4/h7,10,16-20H,5-6,8-9,11-15H2,1-4H3,(H,30,31,33)/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420261 (US10487092, Example 109 | [4-(Dimethylamino)piperi...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCC(CC1)N(C)C |r| Show InChI InChI=1S/C26H31N7O2S/c1-31(2)17-7-10-32(11-8-17)26(34)16-4-5-19-22(12-16)36-25-23(19)24(27-15-28-25)30-20-13-18-6-9-29-33(18)14-21(20)35-3/h6,9,13-17H,4-5,7-8,10-12H2,1-3H3,(H,27,28,30)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420260 (US10487092, Example 108 | [(3S,4S)-3,4-Dihydroxypy...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](O)[C@@H](O)C1 |r| Show InChI InChI=1S/C23H24N6O4S/c1-33-18-10-29-13(4-5-26-29)7-15(18)27-21-20-14-3-2-12(6-19(14)34-22(20)25-11-24-21)23(32)28-8-16(30)17(31)9-28/h4-5,7,10-12,16-17,30-31H,2-3,6,8-9H2,1H3,(H,24,25,27)/t12-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM420258 (US10487092, Example 106 | [(3R)-3-(Dimethylamino)p...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC[C@H](C1)N(C)C |r| Show InChI InChI=1S/C25H29N7O2S/c1-30(2)17-7-9-31(12-17)25(33)15-4-5-18-21(10-15)35-24-22(18)23(26-14-27-24)29-19-11-16-6-8-28-32(16)13-20(19)34-3/h6,8,11,13-15,17H,4-5,7,9-10,12H2,1-3H3,(H,26,27,29)/t15-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair

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