| Reaction Details |
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 | Report a problem with these data |
| Target | Ketol-acid reductoisomerase (NADP(+)) |
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| Ligand | BDBM82142 |
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| Substrate/Competitor | BDBM82146 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 8±0 |
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| Temperature | 303.15±0 K |
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| Ki | 7.656e+4± 1.449e+4 nM |
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| Citation |  Liu, XH; Chen, PQ; Wang, BL; Dong, WL; Li, YH; Xie, XQ; Li, ZM High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Chem Biol Drug Des75:228-32 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Ketol-acid reductoisomerase (NADP(+)) |
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| Name: | Ketol-acid reductoisomerase (NADP(+)) |
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| Synonyms: | Acetohydroxy-acid isomeroreductase | Alpha-keto-beta-hydroxylacil reductoisomerase | ILVC_ECOLI | Ketol-acid reductoisomerase | ilvC |
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| Type: | Enzyme |
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| Mol. Mass.: | 54057.85 |
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| Organism: | Escherichia coli |
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| Description: | P05793 |
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| Residue: | 491 |
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| Sequence: | MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSG
LDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQP
LMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLF
QKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVL
MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
NYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGY
MTDMKRIAVAG
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| BDBM82142 |
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| BDBM82146 |
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| Name | BDBM82142 |
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| Synonyms: | Cyclopropane, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H6O4 |
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| Mol. Mass. | 130.0987 |
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| SMILES | OC(=O)C1(CC1)C(O)=O |
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| Structure | 
|
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