Reaction Details |
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Target | Eukaryotic initiation factor 4A-I |
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Ligand | BDBM50239866 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1667493 (CHEMBL4017289) |
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IC50 | >100000±n/a nM |
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Citation | Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem60:5759-5771 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic initiation factor 4A-I |
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Name: | Eukaryotic initiation factor 4A-I |
Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
Type: | PROTEIN |
Mol. Mass.: | 46146.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864983 |
Residue: | 406 |
Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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BDBM50239866 |
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n/a |
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Name | BDBM50239866 |
Synonyms: | CHEMBL4065018 |
Type | Small organic molecule |
Emp. Form. | C27H23N3O3 |
Mol. Mass. | 437.4898 |
SMILES | O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 |
Structure |
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