Compile Data Set for Download or QSAR

Found 27 hits Enz. Inhib. hit(s) with all data for entry = 50000062   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239868 (CHEMBL4097764) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-13-24-21(16-29(25)15-19-6-2-1-3-7-19)17-30(26(32)28-24)22-9-4-10-23(12-22)33-18-20-8-5-11-27-14-20/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239866 (CHEMBL4065018) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair				3D Structure (crystal)
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells assessed as redu...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239867 (CHEMBL4070179) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccn2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-14-24-20(16-29(25)15-19-7-2-1-3-8-19)17-30(26(32)28-24)22-10-6-11-23(13-22)33-18-21-9-4-5-12-27-21/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239865 (CHEMBL4060106) Show SMILES Fc1cccnc1C1CCc2ccc(cc2O1)N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O Show InChI InChI=1S/C28H23FN4O3/c29-22-7-4-12-30-27(22)24-11-9-19-8-10-21(13-25(19)36-24)33-17-20-16-32(15-18-5-2-1-3-6-18)26(34)14-23(20)31-28(33)35/h1-8,10,12-14,16,24H,9,11,15,17H2,(H,31,35)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239871 (CHEMBL4066070) Show SMILES CCCC1=NN2C(S1)=NC(=O)\C(=C/c1ccc(o1)-c1cccc(c1)C(O)=O)C2=N |c:8,t:3| Show InChI InChI=1S/C20H16N4O4S/c1-2-4-16-23-24-17(21)14(18(25)22-20(24)29-16)10-13-7-8-15(28-13)11-5-3-6-12(9-11)19(26)27/h3,5-10,21H,2,4H2,1H3,(H,26,27)/b14-10-,21-17?	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239861 (CHEMBL4092701) Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239863 (CHEMBL4087449) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50239861 (CHEMBL4092701) Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239872 (CHEMBL4095148) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(CC(F)(F)F)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C24H20F4N4O3/c1-13-7-14-4-5-19(22-16(25)3-2-6-29-22)35-20(14)9-18(13)32-11-15-10-31(12-24(26,27)28)21(33)8-17(15)30-23(32)34/h2-3,6-10,19H,4-5,11-12H2,1H3,(H,30,34)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50239861 (CHEMBL4092701) Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239870 (CHEMBL4061514) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1ccccc1OCc1ccccc1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-23-22(17-29(26)16-20-9-3-1-4-10-20)18-30(27(32)28-23)24-13-7-8-14-25(24)33-19-21-11-5-2-6-12-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50239861 (CHEMBL4092701) Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50239868 (CHEMBL4097764) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-13-24-21(16-29(25)15-19-6-2-1-3-7-19)17-30(26(32)28-24)22-9-4-10-23(12-22)33-18-20-8-5-11-27-14-20/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50239866 (CHEMBL4065018) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50239863 (CHEMBL4087449) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50239866 (CHEMBL4065018) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50239866 (CHEMBL4065018) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239864 (CHEMBL4074763) Show SMILES CN1C(=O)N(Cc2cn(Cc3ccccc3)c(=O)cc12)c1cc2OC(CCc2cc1C)c1ncccc1F Show InChI InChI=1S/C30H27FN4O3/c1-19-13-21-10-11-26(29-23(31)9-6-12-32-29)38-27(21)14-24(19)35-18-22-17-34(16-20-7-4-3-5-8-20)28(36)15-25(22)33(2)30(35)37/h3-9,12-15,17,26H,10-11,16,18H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50239863 (CHEMBL4087449) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50239863 (CHEMBL4087449) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239862 (CHEMBL4102900) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(C)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C23H21FN4O3/c1-13-8-14-5-6-19(22-16(24)4-3-7-25-22)31-20(14)10-18(13)28-12-15-11-27(2)21(29)9-17(15)26-23(28)30/h3-4,7-11,19H,5-6,12H2,1-2H3,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50239868 (CHEMBL4097764) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-13-24-21(16-29(25)15-19-6-2-1-3-7-19)17-30(26(32)28-24)22-9-4-10-23(12-22)33-18-20-8-5-11-27-14-20/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair