| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 3 |
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| Ligand | BDBM50241961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670998 (CHEMBL4021027) |
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| IC50 | 3000±n/a nM |
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| Citation |  Ye, N; Zhu, Y; Liu, Z; Mei, FC; Chen, H; Wang, P; Cheng, X; Zhou, J Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists. Eur J Med Chem134:62-71 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 3 |
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| Name: | Rap guanine nucleotide exchange factor 3 |
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| Synonyms: | CGEF1 | EPAC | EPAC 1 | EPAC1 | Exchange factor directly activated by cAMP 1 | Exchange protein directly activated by cAMP 1 | RAPGEF3 | RPGF3_HUMAN | Rap1 guanine-nucleotide-exchange factor directly activated by cAMP | cAMP-GEFI | cAMP-regulated guanine nucleotide exchange factor I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103769.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104531 |
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| Residue: | 923 |
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| Sequence: | MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
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| BDBM50241961 |
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| n/a |
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| Name | BDBM50241961 |
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| Synonyms: | CHEMBL4081514 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H8ClF3N4O2 |
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| Mol. Mass. | 392.719 |
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| SMILES | FC(F)(F)c1ccc(N\N=C(/C#N)C(=O)c2noc3ccccc23)cc1Cl |
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| Structure | 
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