| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM50250685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1682053 (CHEMBL4032330) |
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| IC50 | 28800±n/a nM |
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| Citation |  Rai, G; Brimacombe, KR; Mott, BT; Urban, DJ; Hu, X; Yang, SM; Lee, TD; Cheff, DM; Kouznetsova, J; Benavides, GA; Pohida, K; Kuenstner, EJ; Luci, DK; Lukacs, CM; Davies, DR; Dranow, DM; Zhu, H; Sulikowski, G; Moore, WJ; Stott, GM; Flint, AJ; Hall, MD; Darley-Usmar, VM; Neckers, LM; Dang, CV; Waterson, AG; Simeonov, A; Jadhav, A; Maloney, DJ Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem60:9184-9204 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
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| Type: | Protein |
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| Mol. Mass.: | 36694.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00338::PDB Code: 4ajp |
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| Residue: | 332 |
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| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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| BDBM50250685 |
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| n/a |
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| Name | BDBM50250685 |
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| Synonyms: | CHEMBL1479261 | US10961200, Compound 62 | US11247971, Cmpd ID 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8F3N3O2S |
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| Mol. Mass. | 339.292 |
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| SMILES | OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1 |
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| Structure | 
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